Background: Steatocystoma multiplex (SM) is an asymptomatic benign skin lesion, characterized by multiple sebum‐containing dermal cysts.Objectives: In this study, we report a novel surgical procedure of removal of the cysts followed by a 5‐fluorouracil injection to fulfill the cosmetic needs of patients with SM.Methods: From January 2023 to January 2024, 35 patients with SM, 2 of whom showed septic steatocystoma, were surgically treated with the novel surgical method in the First Affiliated Hospital of Xi’an Jiaotong University. All procedures were performed in the outpatient operating room. Patients were in close follow‐up for postoperative data, with the most recent follow‐up until March 2024.Results: The surgical intervention is completed within a maximum duration of 40 min for each patient, and all 35 patients with SM exhibited complete postoperative wound healing with no relapse, no cicatrization, and limited hyperpigmentation in mere 4 patients (all within 3 months postoperatively), indicating a favorable overall cosmetic outcome at the latest follow‐up in March 2024.Conclusion: Surgical removal of the cysts with subsequent 5‐fluorouracil injection is a promising and novel operative procedure for SM which is minimally invasive, fulfills the cosmetic needs of the patients, and leads to no recurrence in any case.