Simultaneous Localization and Mapping (SLAM) has become a research hotspot in the field of robots in recent years. However, most visual SLAM systems are based on static assumptions which ignored motion effects. If image sequences are not rich in texture information or the camera rotates at a large angle, SLAM system will fail to locate and map. To solve these problems, this paper proposes an improved ORB-SLAM2 algorithm based on information entropy and sharpening processing. The information entropy corresponding to the segmented image block is calculated, and the entropy threshold is determined by the adaptive algorithm of image entropy threshold, and then the image block which is smaller than the information entropy threshold is sharpened. The experimental results show that compared with the ORB-SLAM2 system, the relative trajectory error decreases by 36.1% and the absolute trajectory error decreases by 45.1% compared with ORB-SLAM2. Although these indicators are greatly improved, the processing time is not greatly increased. To some extent, the algorithm solves the problem of system localization and mapping failure caused by camera large angle rotation and insufficient image texture information.