The required knowledge regarding basic life support (BLS), advanced cardiovascular life support (ACLS), and postresuscitative care in the United States and Europe was updated by the American Heart Association (AHA) and European Resuscitation Council (ERC), respectively, in 2015 [1–3]. These new updates have guided the global treatment strategies of critical and emergency care [1–3]. However, in spite of these new guidelines, some studies have reported that the survival rates and neurological outcomes of patients experiencing out-of-hospital cardiac arrest (OHCA) were still not obviously improved in recent years [4–6]. Resuscitating a patient with OHCA is still a challenge for primary physicians; therefore, better treatment strategies are necessary. Novel categories that focus on postresuscitative care, resuscitation, or shock management are still of interest to scientific researchers. To improve patient outcomes, current guidelines, and knowledge can be clinically applied or even challenged. In this special issue, we would like to provide an opportunity to widely introduce related works discussing shock, cardiac arrest, and resuscitation.