
Human induced pluripotent stem cells (iPSCs) are a type of stem cells that can be derived from human somatic cells by introducing certain transcription factors. Induced pluripotent stem cells can divide indefinitely and are able to differentiate into every cell type, which make them viable for transplantation and individual disease modeling. Recently, various ocular cells, including corneal epithelial‐like cells, retinal pigment epithelium (RPE) cells displaying functions similar to native RPE, photoreceptors, and retinal ganglion cells, have all been successfully derived from iPSCs. Transplantation of these cells in animal models showed great promise for reversing blindness, and the first clinical trial on humans started in 2013. Despite these promising results, more research is in demand for preventing inadvertent tumor growth, developing precise functionality of the cells, and promoting integration into the host tissue.
570, TRANSPLANTATION, PHOTORECEPTOR PRECURSORS, LONG-TERM SAFETY, 610, IN-VITRO, Review Article, RETINAL-PIGMENT EPITHELIUM, MACULAR DEGENERATION, MOUSE, RC31-1245, DIFFERENTIATION, RETINITIS-PIGMENTOSA, Internal medicine, GENERATION
570, TRANSPLANTATION, PHOTORECEPTOR PRECURSORS, LONG-TERM SAFETY, 610, IN-VITRO, Review Article, RETINAL-PIGMENT EPITHELIUM, MACULAR DEGENERATION, MOUSE, RC31-1245, DIFFERENTIATION, RETINITIS-PIGMENTOSA, Internal medicine, GENERATION
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 16 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 10% | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |
