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https://dx.doi.org/10.1155/201...
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Role of IL‐38 and Its Related Cytokines in Inflammation

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2015 English Publisher:WileyJournal:Mediators of Inflammation, volume 2,015 (issn: 0962-9351, eissn: 1466-1861, Copyright policy )
Authors: Xianli Yuan; Xiao Peng; Yan Li; Mingcai Li;

doi: 10.1155/2015/807976

pmid: 25873772

pmc: PMC4383490

Role of IL‐38 and Its Related Cytokines in Inflammation

Abstract

Interleukin‐ (IL‐) 38 is a recently discovered cytokine and is the tenth member of the IL‐1 cytokine family. IL‐38 shares structural features with IL‐1 receptor antagonist (IL‐1Ra) and IL‐36Ra. IL‐36R is the specific receptor of IL‐38, a partial receptor antagonist of IL‐36. IL‐38 inhibits the production of T‐cell cytokines IL‐17 and IL‐22. IL‐38 also inhibits the production of IL‐8 induced by IL‐36γ, thus inhibiting inflammatory responses. IL‐38‐related cytokines, including IL‐1Ra and IL‐36Ra, are involved in the regulation of inflammation and immune responses. The study of IL‐38 and IL‐38‐related cytokines might provide new insights for developing anti‐inflammatory treatments in the near future.

Related Organizations
Keywords

Inflammation, Interleukins, Review Article, Receptors, Interleukin, Interleukin 1 Receptor Antagonist Protein, Pathology, RB1-214, Animals, Cytokines, Humans, Signal Transduction

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
66
Top 10%
Top 10%
Top 10%
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