Background.Chronic nature of the nasal polyps, tendency to recurrence, and lack of satisfying treatment need the diagnostic’s parameters which show early inflammatory state as ferritin and hs-CRP.The Aim of Study.Assessment of hs-CRP and ferritin blood levels in nasal polyps patients in evaluation of treatment efficacy.Methods.All 38 patients were divided into 2 groups. Group I included 19 patients with anti-inflammatory therapy 2 weeks after surgery. Group II included 19 patients without anti-inflammatory therapy 2 weeks after surgery. The levels of hs-CRP and ferritin have been assessed before and 2 and 6 weeks after surgical treatment.Results.Research showed statistically significant difference of ferritin’s concentration between examined groups 6 weeks after surgery (P<0.05) and statistically significant difference of hs-CRP concentration 2 and 6 weeks after surgery (P<0.05).Conclusion.(1) The analysis of serum ferritin and hs-CRP concentrations can be useful in early postoperative detection of inflammatory state in patients with nasal polyps and for the effectiveness of therapy. (2) Lack of correlation between mean ferritin and hs-CRP serum levels, at each diagnostic and monitoring stage, shows that they are independent and cannot be determined interchangeably.