Reports about the extragenital spread ofChlamydia trachomatis (CT)to oropharynx are limited. We report a male patient with progressive tonsillopharyngitis resistant to amoxicillin/clavulanic acid therapy. The patient presented 9 days after an orogenital and oroanal sexual intercourse with a female sex worker. The microimmunofluorescence revealedCTtonsillopharyngitis, and after completing a one-week course ofdoxycycline, the patient recovered completely. More cases ofCTtonsillopharyngitis may be revealed if attention is paid to an association of sexual activity with enduring tonsillopharyngitis.