Photonic crystal fibers are a kind of fiber optics that present a diversity of new and improved features beyond what conventional optical fibers can offer. Due to their unique geometric structure, photonic crystal fibers present special properties and capabilities that lead to an outstanding potential for sensing applications. A review of photonic crystal fiber sensors is presented. Two different groups of sensors are detailed separately: physical and biochemical sensors, based on the sensor measured parameter. Several sensors have been reported until the date, and more are expected to be developed due to the remarkable characteristics such fibers can offer.