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Mediators of Inflammation
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Mediators of Inflammation
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Mediators of Inflammation
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https://dx.doi.org/10.1155/201...
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PGD Synthase and PGD2in Immune Resposne

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2012 English Publisher:WileyJournal:Mediators of Inflammation, volume 2,012, pages 1-6 (issn: 0962-9351, eissn: 1466-1861, Copyright policy )
Authors: Myungsoo Joo; Ruxana T. Sadikot;

doi: 10.1155/2012/503128

pmid: 22791937

pmc: PMC3389719

PGD Synthase and PGD2in Immune Resposne

Abstract

PGD2is formed from arachidonic acid by successive enzyme reactions: oxygenation of arachidonic acid to PGH2, a common precursor of various prostanoids, catalyzed by cyclooxygenase, and isomerization of PGH2to PGD2by PGD synthases (PGDSs). PGD2can be either pro- or anti-inflammatory depending on disease process and etiology. The anti-inflammatory and immunomodulatory attributes of PGDS/PGD2provide opportunities for development of novel therapeutic approaches for resistant infections and refractory inflammatory diseases. This paper highlights the role of PGD synthases and PGD2 in immune inflammatory response.

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Keywords

Inflammation, Intramolecular Oxidoreductases, Prostaglandin D2, Pathology, RB1-214, Animals, Humans, Review Article, Lipocalins

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
99
Top 1%
Top 10%
Top 10%
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gold
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