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Journal of Immunology Research
Article . 1989 . Peer-reviewed
License: CC BY
Data sources: Crossref
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Journal of Immunology Research
Article
License: CC BY
Data sources: UnpayWall
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PubMed Central
Article . 1990
License: CC BY
Data sources: PubMed Central
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Immunoglobulin λ Gene Rearrangement Can Precede κ Gene Rearrangement

Authors: Berg, Jörg; Mcdowell, Mindy; Jäck, Hans-Martin; Wabl, Matthias;

Immunoglobulin λ Gene Rearrangement Can Precede κ Gene Rearrangement

Abstract

Immunoglobulin genes are generated during differentiation of B lymphocytes by joining gene segments. A mouse pre‐B cell contains a functional immunoglobulin heavy‐chain gene, but no light‐chain gene. Although there is only one heavy‐chain locus, there are two lightchain loci: κ and λ.It has been reported that κ loci in the germ‐line configuration are never (in man) or very rarely (in the mouse) present in cells with functionally rearranged λ‐chain genes. Two explanations have been proposed to explain this: (a) the ordered rearrangement theory, which postulates that light‐chain gene rearrangement in the pre‐B cell is first attempted at the κ locus, and that only upon failure to produce a functional κ chain is there an attempt to rearrange the λ locus; and (b) the stochastic theory, which postulates that rearrangement at the λ locus proceeds at a rate that is intrinsically much slower than that at the κ locus. We show here that λ‐chain genes are generated whether or not the κ locus has lost its germ‐line arrangement, a result that is compatible only with the stochastic theory.

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
16
Average
Average
Average
Green
gold