Cellular and molecular neuroscience of alcoholism

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1997 English Publisher:American Physiological SocietyJournal:Physiological Reviews, volume 77, pages 1-20 (issn: 0031-9333, eissn: 1522-1210,

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Authors: I, Diamond; A S, Gordon;

doi: 10.1152/physrev.1997.77.1.1

pmid: 9016298

Cellular and molecular neuroscience of alcoholism

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Abstract

Recent advances in neuroscience have made it possible to investigate the pathophysiology of alcoholism at a cellular and molecular level. Evidence indicates that ethanol affects hormone- and neurotransmitter-activated signal transduction, leading to short-term changes in regulation of cellular functions and long-term changes in gene expression. Such changes in the brain probably underlie many of the acute and chronic neurological events in alcoholism. In addition, genetic vulnerability also plays a role in alcoholism and, perhaps, in alcoholic medical disorders.

Related Organizations

University of California, San Francisco
United States
San Francisco General Hospital
United States

Keywords

Alcoholism, Ethanol, Animals, Humans, Signal Transduction

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