Calcium Signaling Through CatSper Channels in Mammalian Fertilization

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2010 English Publisher:American Physiological SocietyJournal:Physiology, volume 25, pages 165-175 (issn: 1548-9213, eissn: 1548-9221,

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Authors: Dejian, Ren; Jingsheng, Xia;

doi: 10.1152/physiol.00049.2009

pmid: 20551230

Calcium Signaling Through CatSper Channels in Mammalian Fertilization

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Abstract

The molecular mechanisms underlying Ca2+entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility. We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca2+entry through CatSper channels instead of acting on CaVand CNG channels as previously thought.

Related Organizations

University of Pennsylvania
United States

Keywords

Male, Mice, Knockout, Mice, Fertilization, Models, Animal, Sperm Motility, Animals, Calcium Channels, Calcium Signaling

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