PKA, Germ Cells, and Fertility

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2007 English Publisher:American Physiological SocietyJournal:Physiology, volume 22, pages 40-46 (issn: 1548-9213, eissn: 1548-9221,

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Authors: Kimberly A, Burton; G Stanley, McKnight;

doi: 10.1152/physiol.00034.2006

pmid: 17289929

PKA, Germ Cells, and Fertility

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Abstract

Temporal and spatial regulation of PKA activity are essential for vigorous sperm motility and for the resumption of meiosis in oocytes, two events required for successful fertilization. Genetic mutations in mice that affect PKA signaling in germ cells lead to infertility and illustrate the importance of this pathway in mammalian reproduction.

Related Organizations

University of Washington
United States
University of Mary
United States

Keywords

Meiosis, Fertility, Germ Cells, Oogenesis, Animals, Humans, Spermatogenesis, Cyclic AMP-Dependent Protein Kinases

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