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Physiology
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Physiology
Article . 2014
Data sources: European Research Council (ERC)
Physiology
Article . 2014 . Peer-reviewed
Data sources: Crossref
Physiology
Article . 2015
Data sources: Europe PubMed Central
https://dx.doi.org/10.1152/phy...
Article
Data sources: Microsoft Academic Graph
MPG.PuRe
Article . 2014
Data sources: MPG.PuRe
http://dx.doi.org/10.1152/phys...
Article . Peer-reviewed
Data sources: European Union Open Data Portal
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How Could SNARE Proteins Open a Fusion Pore?

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2014 English Publisher:American Physiological SocietyJournal:Physiology, volume 29, pages 278-285 (issn: 1548-9213, eissn: 1548-9221, Copyright policy )Funded by:EC | THE FUSION MACHINE
Authors: Q. Fang; M. Lindau;

doi: 10.1152/physiol.00026.2013

pmid: 24985331

pmc: PMC4103061

handle: 11858/00-001M-0000-0019-FEC0-3 , 11858/00-001M-0000-002B-1110-3

How Could SNARE Proteins Open a Fusion Pore?

Abstract

The SNARE (Soluble NSF Attachment protein REceptor) complex, which in mammalian neurosecretory cells is composed of the proteins synaptobrevin 2 (also called VAMP2), syntaxin, and SNAP-25, plays a key role in vesicle fusion. In this review, we discuss the hypothesis that, in neurosecretory cells, fusion pore formation is directly accomplished by a conformational change in the SNARE complex via movement of the transmembrane domains.

Related Organizations
Keywords

Protein Conformation, Animals, Humans, Synaptic Vesicles, SNARE Proteins, Membrane Fusion, Neurosecretory Systems

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 58
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
58
Top 10%
Top 10%
Top 1%
bronze