
pmid: 18073412
Tandem mass spectrometry coupled to liquid chromatography (LC-MS/MS) allows identification of proteins in a complex mixture without need for protein purification (“shotgun” proteomics). Recent progress in LC-MS/MS-based quantification, phosphoproteomic analysis, and targeted LC-MS/MS using multiple reaction monitoring (MRM) has made LC-MS/MS a powerful tool for the study of cell physiology.
Proteomics, Systems Integration, Tandem Mass Spectrometry, Intracellular Signaling Peptides and Proteins, Animals, Humans, Phosphoproteins, Cell Physiological Phenomena, Chromatography, Liquid, Signal Transduction
Proteomics, Systems Integration, Tandem Mass Spectrometry, Intracellular Signaling Peptides and Proteins, Animals, Humans, Phosphoproteins, Cell Physiological Phenomena, Chromatography, Liquid, Signal Transduction
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