Why Calcium-Stimulated Adenylyl Cyclases?

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2004 English Publisher:American Physiological SocietyJournal:Physiology, volume 19, pages 271-276 (issn: 1548-9213, eissn: 1548-9221,

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Authors: Gregory D, Ferguson; Daniel R, Storm;

doi: 10.1152/physiol.00010.2004

pmid: 15381755

Why Calcium-Stimulated Adenylyl Cyclases?

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Abstract

The Ca2+/calmodulin-stimulated adenylyl cyclases, AC1 and AC8, play a critical role in several forms of neuroplasticity, including long-lasting long-term potentiation (L-LTP) and long-term memory (LTM). By coupling neuronal activity and Ca2+increases to the production of cAMP, AC1 and AC8 activate cAMP-dependent signal transduction and transcriptional pathways critical for L-LTP and LTM.

Related Organizations

University of Mary
United States
University of Washington
United States

Keywords

Neurons, Calmodulin, Animals, Calcium, Adenylyl Cyclases, Signal Transduction

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