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AJP Endocrinology and Metabolism
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AJP Endocrinology and Metabolism
Article . 2009 . Peer-reviewed
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AJP Endocrinology and Metabolism
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AJP Endocrinology and Metabolism
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Acyl-coenzyme A:cholesterol acyltransferases

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2009 English Publisher:American Physiological SocietyJournal:American Journal of Physiology-Endocrinology and Metabolism, volume 297, pages E1-E9 (issn: 0193-1849, eissn: 1522-1555, Copyright policy )
Authors: Bo-Liang Li; Ta-Yuan Chang; Catherine C.Y. Chang; Yasuomi Urano;

doi: 10.1152/ajpendo.90926.2008

pmid: 19141679

pmc: PMC2711667

Acyl-coenzyme A:cholesterol acyltransferases

Abstract

The enzymes acyl-coenzyme A (CoA):cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues. This chapter summarizes the current knowledge on ACAT-related research in two areas: 1) ACAT genes and proteins and 2) ACAT enzymes as drug targets for atherosclerosis and for Alzheimer's disease.

Related Organizations
Keywords

Protein Conformation, Molecular Sequence Data, Animals, Humans, Amino Acid Sequence, Lipid Metabolism, Models, Biological, Sterol O-Acyltransferase

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 414
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
414
Top 1%
Top 1%
Top 1%
bronze
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