Bone marrow-derived NGFR-positive dendritic cells regulate arterial remodeling
Copyright policy )Bone marrow-derived NGFR-positive dendritic cells regulate arterial remodeling
We propose a new concept of arterial remodeling after injury in which bone marrow-derived NGFR+ dendritic cells inhibit neointimal progression mediated by apoptosis. NGFR+ dendritic cells promote anti-inflammatory MRC1+ M2 macrophage accumulation and production of interleukin-10, inhibiting smooth muscle cell proliferation within the neointima. In a clinical study, insufficient mobilization of NGFR+ peripheral mononuclear cells in acute coronary syndrome was an independent risk factor for 9-mo nontargeted coronary intimal progression.
Male, Mice, Knockout, Macrophages, Myocytes, Smooth Muscle, Apoptosis, Bone Marrow Cells, Dendritic Cells, Receptors, Nerve Growth Factor, Vascular Remodeling, Middle Aged, Muscle, Smooth, Vascular, Interleukin-10, Mice, Inbred C57BL, Mice, Neointima, Animals, Humans, Female, Acute Coronary Syndrome, Cell Proliferation
Male, Mice, Knockout, Macrophages, Myocytes, Smooth Muscle, Apoptosis, Bone Marrow Cells, Dendritic Cells, Receptors, Nerve Growth Factor, Vascular Remodeling, Middle Aged, Muscle, Smooth, Vascular, Interleukin-10, Mice, Inbred C57BL, Mice, Neointima, Animals, Humans, Female, Acute Coronary Syndrome, Cell Proliferation
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