Mitochondrial sequencing identifies long noncoding RNA features that promote binding to PNPase
Copyright policy )Mitochondrial sequencing identifies long noncoding RNA features that promote binding to PNPase
Long noncoding RNAs (lncRNAs) are relatively novel RNAs with increasingly prominent roles in regulating genetic expression, mainly in the nucleus but more recently in regions such as the mitochondrion. This study explores how lncRNAs interact with polynucleotide phosphorylase (PNPase), a protein that regulates RNA import into the mitochondrion. Machine learning identified several RNA structural features that improved lncRNA binding to PNPase, which may be useful in targeting RNA therapeutics to the mitochondrion.
- West Virginia University Research Corporation United States
- West Virginia University United States
- West Virginia University Hospitals United States
Polyribonucleotide Nucleotidyltransferase, Mice, Animals, Humans, RNA, Long Noncoding, Mitochondria, Protein Binding
Polyribonucleotide Nucleotidyltransferase, Mice, Animals, Humans, RNA, Long Noncoding, Mitochondria, Protein Binding
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