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Fracture Risk Score and Absolute Risk of Fracture

Authors: Henry, Margaret; Pasco, Julie; Merriman, Elizabeth; Zhang, Yu; Sanders, Kerrie; Kotowicz, Mark; Nicholson, Geoffrey;

Fracture Risk Score and Absolute Risk of Fracture

Abstract

To report the 5- and 10-year absolute risk of fracture associated with the previously reported fracture risk (FRISK) score.All participants gave written, informed consent, and the Barwon Health Human Research Ethics Committee approved the study. An age-stratified population-based sample of women aged 60 years and older (n = 600) was recruited during 1994-1996. FRISK scores of 0-10 incorporating bone mineral density (BMD) at two sites (hip and spine), falls scores in the previous 12 months of 1-4, weight, and number of fractures as an adult were calculated. Fractures of the hip, spine, humerus, and wrist were ascertained during a median follow-up period of 9.6 years (interquartile range, 6.6-10.5). The cumulative probability of fracture at 5 and 10 years after baseline measurements was calculated by using actuarial methods. The utility of this model was compared with other FRISK algorithms, including the World Health Organization FRISK assessment tool FRAX designed for United Kingdom and that designed for the United States and the Garvan nomogram (Australia).This study supplies the 5- and 10-year absolute risk of fracture associated with all levels of the FRISK score. While there are modest differences in absolute risk of fracture seen for different numbers of prior fractures, the more marked differences occur across the different categories of falls scores and different categories of BMD. The receiver operating characteristic curves showed no significant difference in area under the curve for all four absolute risk of fracture algorithms.Absolute risk of fracture can be determined by using readily obtainable clinical information that may aid treatment decisions.

Keywords

Aged, 80 and over, Middle Aged, Risk Assessment, Sensitivity and Specificity, Nuclear Medicine & Medical Imaging, Fractures, Bone, ROC Curve, Bone Density, Risk Factors, Area Under Curve, 2741 Radiology Nuclear Medicine and imaging, Linear Models, Humans, Female, Longitudinal Studies, Prospective Studies, Radiology, Algorithms, Osteoporosis, Postmenopausal, Aged

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Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
20
Top 10%
Average
Top 10%
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