In 1966 Hermans and his co-workers (1) reported eight cases of dysgammaglobulinemia associated with nodular lymphoid hyperplasia of the small intestine. Characteristically, these patients demonstrated an unusual susceptibility to infection, chronic or intermittent diarrhea, reduced concentration of gamma globulins, and roentgenologic evidence of nodular defects in the intestine. Since that report, two more patients have been observed with this combination of findings. The present report is primarily concerned with the roentgenologic appearance of these nodular defects in 10 patients. These tiny, nodular, filling defects are usually evident on films of the upper part of the small intestine and are located primarily in the duodenum and jejunum, although they may also be seen in the terminal part of the ileum and the right colon. Clinical Study All the 10 patients (6 men and 4 women) gave a history of either unusual susceptibility to infection or chronic diarrhea which had persisted for various periods. The ...