The use of Cholografin (methylglucamine iodip-amide) as a contrast agent for cholangiography has been handicapped by marked nausea and frequent vomiting at the time of injection. To circumvent these side-effects, the manufacturer has suggested an injection time of ten minutes. In our experience, even if one adheres to this recommendation, nausea is almost universal and vomiting common. In an effort to overcome these side-effects, we have diluted the usual dose of Cholografin (20 cc) in 100 cc of 5 per cent dextrose solution and administered the combination as an intravenous drip over a period of ten minutes. With this method of administration, nausea is unusual and vomiting rare. A comparison of 50 studies performed in the routine manner with 50 intravenous Cholangiographie examinations by the drip infusion technic showed no difference in the quality of the examination. The same level of liver function, as determined by serum chemistries, was found necessary for a satisfactory examination. The time densit...