Although folic acid antagonists have been widely used in recent years, there have been only a few reports of their effects on Vitamin C metabolism. Recently, we have seen a patient with widespread neuroblastoma in whom typical scorbutic changes developed in the long bones during the course of aminopterin therapy. Case Report B. P., a 16-month-old white girl, was admitted to the University Hospital on Dec. 16, 1952, with progressive bilateral exophthalmos, more marked on the left; edema, venous engorgement and capillary dilatation of the upper eyelids; hepatomegaly; and otitis media of the right ear. Admission roentgen studies revealed multiple osteolytic lesions (Fig. 1) considered to be those of a metastatic neuroblastoma, in the skull, pelvis, and long bones. The latter diagnosis was confirmed by bone-marrow studies and a biopsy of the right tibia. The otitis media was treated with penicillin, streptomycin, and hydrogen peroxide irrigations. Beginning on Jan. 14, 1953, cortisone was given in doses of 50...