The term “syphilis of the stomach” is applied to the lesion that occurs in the tertiary stage of the disease. Although the incidence is much lower than that of ulcer, cancer, or gastritis, the condition is not rare, as a review of the literature indicates. It is estimated that in the United States 0.3 per cent of patients with syphilis have involvement of the stomach (Bockus). In review of the cases of syphilis seen at University Hospital in the past ten years, however, only two with gastric lesions fulfilling the necessary criteria were found. In the majority of cases reported in the literature, the diagnosis was made clinically, only a few being established histopathologically. The criteria usually accepted for the clinical diagnosis of gastric syphilis are: (1) untreated tertiary syphilis, (2) a demonstrable roentgen defect, (3) presence of gastric symptoms, (4) inability to alleviate symptoms or effect any improvement in the anatomic x-ray defect by orthodox methods of management without antisyphiliti...