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The Experimental Production of Extraskeletal Bone-Forming Neoplasms in the Rat

Authors: M. R. Curtis; W. F. Dunning;

The Experimental Production of Extraskeletal Bone-Forming Neoplasms in the Rat

Abstract

Bone-containing neoplasms which have no connection with the skeleton are occasionally observed in man. Raso (1), in 1937, reported an osteoid chondrosarcoma of the breast and collected from the literature, dating from 1835, 74 mammary gland tumors containing bone or cartilage. Of the malignant tumors in this group, 27 were osteosarcomata, chondrosarcomata, or osteochondrosarcomata, 7 were primarily carcinomata, and 5 were mixed tumors. Binkley and Stewart (2) in 1940 discussed 9 cases of tumors of epithelial origin resembling osteogenic sarcomata and concluded that the most important alterations leading to the appearance of the structure of osteogenic sarcoma are the laying down of dense hyaline tissue and the development of a cavernous telangiectatic type of circulation favoring stasis. They recognized that these features fail to explain the structure of cartilage in these so-called mixed tumors. Allen (3), 1940, described 4 mixed tumors of the mammary glands of dogs and one from the human breast. He con...

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
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