Histamine Release by Contrast Media

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1971 English Publisher:Radiological Society of North America (RSNA)Journal:Radiology, volume 100, pages 683-686 (issn: 0033-8419, eissn: 1527-1315,

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Authors: E C, Lasser; A, Walters; S R, Reuter; J, Lang;

doi: 10.1148/100.3.683

pmid: 4105399

Histamine Release by Contrast Media

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Abstract

The blood draining organs with a high histamine content was sampled and elevation of plasma histamine was found to result from injections of certain contrast media. All methylglucamine contrast media tested to date (acetrizoate, diatrizoate, and iodipamide) produced such elevations. Methylglucamine chloride also caused elevation of plasma histamine. Some “allergic” reactions to contrast media may be explained on this basis.

Keywords

Contrast Media, Tubocurarine, Amino Sugars, Sodium Chloride, Histamine Release, Models, Biological, Drug Hypersensitivity, Dogs, Glucose, Liver, Animals, Salts, Lung, Histamine

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