The pace and the emphasis have changed, in recent years, in work on the pituitary and adrenal cortex. The excitement of the 1949-1950 disco veries of new therapeutic uses of corticotropin and cortisone has subsided, and in its place one finds a new focus of attention on the control of the function of the adenohyp ophysis. Newer methods of separating and identifying small amounts of steroids have facilitated the study of the biosynthesis and catabolism of the adrenocortical hormon es. The recent discovery of aldos­ terone has stimulated anew work on the adrenal involvement in