Name: GENETIC RISK ASSESSMENT
Creator: Udo H. Ehling
Keywords: Mice, Germ Cells, Dose-Response Relationship, Drug, Mutagenesis, Mutagenicity Tests, Risk Factors, Mutation, Animals, Humans, Dose-Response Relationship, Radiation

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1991 English Publisher:Annual ReviewsJournal:Annual Review of Genetics, volume 25, pages 255-280 (issn: 0066-4197, eissn: 1545-2948,

Authors: Udo H. Ehling;

doi: 10.1146/annurev.ge.25.120191.001351 , 10.1146/annurev.genet.25.1.255

pmid: 1812809

GENETIC RISK ASSESSMENT

- Summary
- Subjects
- Metrics

Abstract

INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255 METHODS FOR DETECTING GERM CELL MUTATIONS IN MAMMALS . . . . . . . . . 257 Recessi ve Spec ific-Loc us M uta ti ons in M ic e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257 D ominan t M uta ti ons in Mice . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259 The M ultip le Endp oin t Appr oach .. . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .... . . . . . . . . . . . ... . . . . . 262 Q UANTIFICATION OF GENETIC RISK . . . . . . . . . . . . . . . ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . 264 Indirec t Risk Es tima ti on (D oub ling D ose Me th od ) . . . . . . . . . . . . . . . . . . ......... 264 D i re ct Risk Estima ti on . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . 269 Cri tica l Eva lua ti on of Risk E stima ti on . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 272 PERSPECTIVE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 274 CONCLUSIONS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . 275

Keywords

Mice, Germ Cells, Dose-Response Relationship, Drug, Mutagenesis, Mutagenicity Tests, Risk Factors, Mutation, Animals, Humans, Dose-Response Relationship, Radiation, Cataract, Genes, Dominant

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	42
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%