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ACYL-COENZYME A:CHOLESTEROL ACYLTRANSFERASE

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1997 English Publisher:Annual ReviewsJournal:Annual Review of Biochemistry, volume 66, pages 613-638 (issn: 0066-4154, eissn: 1545-4509,

Authors: Catherine C.Y. Chang; Ta-Yuan Chang; Dong Cheng;

doi: 10.1146/annurev.biochem.66.1.613

pmid: 9242919

ACYL-COENZYME A:CHOLESTEROL ACYLTRANSFERASE

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Abstract

Due to its presumed role in regulating cellular cholesterol homeostasis, and in various pathophysiological conditions, acyl-coenzyme A:cholesterol acyltransferase (ACAT) has attracted much attention. Cloning the ACAT gene provides the necessary tool to advance molecular studies of this enzyme. The topics reviewed in this chapter include the pathophysiological roles of ACAT, the biochemistry and molecular biology of the ACAT protein and the ACAT gene, and the mode of regulation by sterol or nonsterol agents in mammalian cells. In addition, we present a working model linking the presumed allosteric property of ACAT with cholesterol trafficking into and out of the endoplasmic reticulum.

Related Organizations

Dartmouth College
United States

Keywords

Cholesterol, Molecular Sequence Data, Animals, Humans, Amino Acid Sequence, Endoplasmic Reticulum, Gene Expression Regulation, Enzymologic, Sterol O-Acyltransferase

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	518
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%