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Proton Beam Therapy

Authors: L J Verhey; J E Munzenrider;

Proton Beam Therapy

Abstract

Conventional radiotherapy with high energy photons and electrons has been remarkably successful in treating many localized tumors. However, if tumors are large or are located very close to critical normal structures, it becomes very difficult to deliver a tumoricidal dose to the entire tumor volume without compromising the function of these adjacent organs. In such situations the local tumor control probability may be enhanced by improving the therapeutic ratio, defined as the ratio of the probability of tumor control to the probability of normal tissue injury. An increase in the therapeutic ratio may be' obtained by choosing a radiation modality that is more effective at killing tumor cells than normal cells or by employing a type of radiation that provides improved dose distribution relative to that achievable by conventional radiation modalities. Historically, great improvements in local control rates of deep-seated tumors were obtained through an increase in the energy of photon treatment beams. This occurred both at the time of the introduction of the 60 Cobalt teletherapy unit into radiation therapy, replacing X-ray machines with maximum energies of about 300 kVp, and with the introduction of high energy electron accelerators capable of producing bremsstrahlung beams with energies in the supervoltage range, i.e. above 2 MeV, such as Betatrons and linear accelerators (4). Since the introduc­ tion of high energy photon beams, physicists have continued to try to improve dose distributions through the use of sophisticated treatment plans, including multiportal and rotational techniques, beam modifiers such as compensating wedges, etc, and by the development of computer­ directed dynamic therapy techniques (8).

Keywords

Adult, Male, Spinal Neoplasms, Skull Neoplasms, Prostatic Neoplasms, Sarcoma, Soft Tissue Neoplasms, Middle Aged, Patient Care Planning, Radiotherapy, High-Energy, Head and Neck Neoplasms, Neoplasms, Carcinoma, Squamous Cell, Chordoma, Humans, Female, Particle Accelerators, Protons, Melanoma, Aged

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    influence
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
32
Average
Top 10%
Top 10%
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