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Annual Review of Genetics
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Annual Review of Genetics
Article . 2012 . Peer-reviewed
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Annual Review of Genetics
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Annual Review of Genetics
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Neural Regeneration in Caenorhabditis elegans

descriptionPublicationkeyboard_double_arrow_right Article 15 Dec 2012Publisher:Annual ReviewsJournal:Annual Review of Genetics, volume 46, pages 499-513 (issn: 0066-4197, eissn: 1545-2948, Copyright policy )
Authors: Marc Hammarlund; Rachid El Bejjani;

doi: 10.1146/annurev-genet-110711-155550

pmid: 22974301

pmc: PMC3700416

Neural Regeneration in Caenorhabditis elegans

Abstract

Axon regeneration is a medically relevant process that can repair damaged neurons. This review describes current progress in understanding axon regeneration in the model organism Caenorhabditis elegans. Factors that regulate axon regeneration in C. elegans have broadly similar roles in vertebrate neurons. This means that using C. elegans as a tool to leverage discovery is a legitimate strategy for identifying conserved mechanisms of axon regeneration.

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Keywords

Neurons, MAP Kinase Signaling System, Axotomy, MAP Kinase Kinase Kinases, Microtubules, Axons, Nerve Regeneration, MicroRNAs, Models, Animal, Cyclic AMP, Animals, Trauma, Nervous System, Calcium Channels, Caenorhabditis elegans, Caenorhabditis elegans Proteins

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 36
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
36
Top 10%
Top 10%
Top 10%
bronze