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The Hepatitis B Virus Receptor

Name: The Hepatitis B Virus Receptor
Creator: Wenhui Li
Keywords: 0301 basic medicine, Hepatitis B virus, 03 medical and health sciences, Membrane Glycoproteins, Symporters, Animals, Humans, Organic Anion Transporters, Sodium-Dependent, Receptors, Cell Surface, Hepatitis Delta Virus

descriptionPublicationkeyboard_double_arrow_right Article 13 Nov 2015Publisher:Annual ReviewsJournal:Annual Review of Cell and Developmental Biology, volume 31, pages 125-147 (issn: 1081-0706, eissn: 1530-8995,

Authors: Wenhui Li;

doi: 10.1146/annurev-cellbio-100814-125241

pmid: 26436705

The Hepatitis B Virus Receptor

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Abstract

Hepatitis B virus (HBV) infection affects 240 million people worldwide. A liver-specific bile acid transporter named the sodium taurocholate cotransporting polypeptide (NTCP) has been identified as the cellular receptor for HBV and its satellite, the hepatitis D virus (HDV). NTCP likely acts as a major determinant for the liver tropism and species specificity of HBV and HDV at the entry level. NTCP-mediated HBV entry interferes with bile acid transport in cell cultures and has been linked with alterations in bile acid and cholesterol metabolism in vivo. The human liver carcinoma cell line HepG2, complemented with NTCP, now provides a valuable platform for studying the basic biology of the viruses and developing treatments for HBV infection. This review summarizes critical findings regarding NTCP's role as a viral receptor for HBV and HDV and discusses important questions that remain unanswered.

Related Organizations

National Institute of Biological Sciences, Beijing
China (People's Republic of)

Keywords

Hepatitis B virus, Membrane Glycoproteins, Symporters, Animals, Humans, Organic Anion Transporters, Sodium-Dependent, Receptors, Cell Surface, Hepatitis Delta Virus, Carrier Proteins

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	64
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%