The processing of biomedical signals took many steps forward in the two decades that followed the introduction of digital computers to the field in the late 50s. Along with my colleagues at the Central Institute for the Deaf and at the Biomedical Computer Laboratory, I was privileged to participate in this exciting early period of biomedical computing. Some of my experiences with projects, both successful and unsuccessful, in evoked response audiometry, neurophysiology, fetal electrocardiography, radiation treatment planning, electrocardiographic rhythm analysis and ambulatory monitoring of electrocardiographic rhythms are described. These recollections give less attention to scientific results than they do to selected anecdotes and observations.