Histograms are frequently used to represent the distribution of data values in an attribute of a relation. Most previous work has focused on identifying the optimal histogram (given a limited number of buckets) for a single attribute independent of other attributes/histograms . In this paper, we propose the idea of global optimization of histograms , i.e., single-attribute histograms for a set of attributes are optimized collectively so as to minimize the overall error in using the histograms. The idea is to allocate more buckets to histograms whose attributes are more frequently used and/or distributions are highly skewed. While the accuracy of some histograms is penalized (being assigned fewer buckets), we expect the global error to be low compared to the traditional method (of allocating equal number of buckets to each histogram). We propose two algorithms to determine the histograms to construct for a collection of attributes. The first is based on dynamic programming, and the second is a greedy algorithm. We compare the overall error of these algorithms against the traditional method. Extensive experiments are conducted and the results confirm the benefits of global optimal histograms in reducing the overall error. The extent of improvement depends on the data and query distributions, ranging from no benefit when there is no significant differences in the data distributions to over a factor of 100 reduction in error in some cases we tried. The time to compute global optimal histogram using dynamic programming is much longer than the time to compute optimal histograms separately for each attribute, and the difference widens at a faster rate as the number of histograms increases. With the greedy algorithm, the time penalty is small, but the error reduction is somewhat less as well. We propose a third algorithm, called greedy algorithm with remedy, that has running time similar to the greedy algorithm, but produces results close to global optimum. In fact, in every experiment that we tried, this algorithm found the exact global optimum.