Since 2019 the authors of this article were involved in the digital acquisition and storytelling of artifacts belonging to museum collections. This work showcases on purpose various related case studies to illustrate key issues in the field. They are the Orcinus Citoniensis paleontological finding (representative of a complex geometry to be acquired), the Annunciation by Beato Angelico (representative of materials with articulate behaviors to light such as the gold foil and tempera), and the Giovanni Battista Amici’s Microscope (representative of non-cooperative specular materials). Since they refer to such different contests, they are a valid test field to bring into the discussion methods and techniques for: — the digitization and interactive representation of multicomponent finds; — a reliable visualization of pictorial works with complex optical behaviors; — a cost-effective, rapid digitization of extensive collections with non-cooperating materials. The article outlines a pipeline from accurate digitization to 3D modeling, texturing, and optimization, culminating in the production of interactive experiences. The aim is the introduction of our experience in authoring high-resolution digital surrogates for scholars and museum visitors, to be explored in museums and cultural institutions through conventional devices or digital interactive kiosks. It emphasizes logistical challenges in photogrammetry for acquiring artifacts, including 3D or 2D objects, paleontological finds, and optically non-cooperating items, with a focus on accurate color acquisition and rendering. The developed pipeline enhances the user experience of 3D digital replicas via visualization apps designed for exhibitions and permanent collections.