Misinformation poses a threat to democracy and to people’s health. Reliability criteria for news websites can help people identify misinformation. But despite their importance, there has been no empirically substantiated list of criteria for distinguishing reliable from unreliable news websites. We identify reliability criteria, describe how they are applied in practice, and compare them to prior work. Based on our analysis, we distinguish between manipulable and less manipulable criteria and compare politically diverse laypeople as end-users and journalists as expert users. We discuss 11 widely recognized criteria, including the following 6 criteria that are difficult to manipulate: content, political alignment, authors, professional standards, what sources are used, and a website’s reputation. Finally, we describe how technology may be able to support people in applying these criteria in practice to assess the reliability of websites.