Healthcare organizations increasingly rely on electronic information to optimize their operations. Information of high diversity from various sources accentuate the relevance and importance of information quality (IQ). The quality of information needs to be improved to support a more efficient and reliable utilization of healthcare information systems (IS). This can only be achieved through the implementation of initiatives followed by most users across an organization. The purpose of this study is to examine how awareness of IS users about IQ issues would affect their IQ behavior. Based on multiple theoretical frameworks, it is hypothesized that different aspects of user motivation mediate the relationship between the awareness on both beneficial and problematic situations and IQ practice inclination. In addition, social influence and facilitating condition moderate the relationship between IQ practice inclination and overt IQ practice. The theoretical and practical implications of findings are discussed, especially how to enhance IQ compliance in the healthcare settings.