Biosynthesis of Cardiolipin in Mitochondria

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1971 English Publisher:Canadian Science PublishingJournal:Canadian Journal of Biochemistry, volume 49, pages 1,117-1,124 (issn: 0008-4018,

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Authors: J B, Davidson; N Z, Stanacev;

doi: 10.1139/o71-161

pmid: 4334991

Biosynthesis of Cardiolipin in Mitochondria

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Abstract

Conversion of sn-glycero-3-phosphate-2-3H to cardiolipin in mitochondria isolated from guinea pig liver has been established. Cardiolipin thus formed was isolated and characterized. Under similar conditions, microsomes were not able to catalyze the biosynthesis of cardiolipin in a detectable amount. The mechanism for the biosynthesis of cardiolipin in mitochondria, similar to that described in bacteria, is suggested. These results have established mitochondrial capability to synthesize polyglycerophosphatides.

Keywords

Manganese, Detergents, Guinea Pigs, Mitochondria, Liver, Cytosine Nucleotides, Phosphatidylinositols, Tritium, Models, Biological, Chromatography, DEAE-Cellulose, Glycerides, Kinetics, Surface-Active Agents, Glycerophosphates, Microsomes, Liver, Phosphatidylcholines, Animals, Calcium, Magnesium, Copper, Phospholipids

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