Structural features of trinucleotide repeats associated with DNA expansion

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2001 English Publisher:Canadian Science PublishingJournal:Biochemistry and Cell Biology, volume 79, pages 325-336 (issn: 0829-8211, eissn: 1208-6002,

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Authors: I V, Kovtun; G, Goellner; C T, McMurray;

doi: 10.1139/o01-101 , 10.1139/bcb-79-3-325

pmid: 11467746

Structural features of trinucleotide repeats associated with DNA expansion

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Abstract

The mechanism of DNA expansion is not well understood. Recent evidence from genetic, in vivo, and in vitro studies has suggested a link between the formation of alternative DNA secondary structures by trinucleotide repeat tracts and their propensity to undergo expansion. This review will focus on structural features and the mechanism of expansion relevant to human disease.Key words: expansion, hairpin, trinucleotide repeat, polymerase slippage, recombination, repair.

Related Organizations

Mayo Clinic
United States

Keywords

DNA Replication, DNA Repair, Animals, Humans, Nucleic Acid Conformation, Neurodegenerative Diseases, DNA, Trinucleotide Repeat Expansion

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