descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1947 English Publisher:Canadian Science PublishingJournal:Canadian Journal of Research, volume 25e, pages 175-180 (issn: 1923-4287,

Authors: Christine E. Rice; G. B. Reed; L. C. Smith; E. F. Pallister;

doi: 10.1139/cjr47e-017 , 10.1139/cjr47e-016

pmid: 20264580 , 20264579

CLOSTRIDIUM BOTULINUM TYPE B TOXOIDS

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Abstract

Fluid and alum-precipitated C. botulinum Type B toxoids were prepared by methods very similar to those used in the production of Type A toxoid, as described in a preceding paper. These Type B toxoids had little protective effect in mice but induced a moderately high degree of immunity in guinea-pigs as shown by their resistance to multiple lethal doses of Type B toxin and the development of Type B antitoxin. A relationship was observed between the Type B antitoxic titre and resistance to Type B toxin.

Keywords

Clostridium, Botulinum Toxins, Clostridium botulinum type A, Clostridium botulinum type B, Humans, Botulinum Toxins, Type A, Toxoids

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