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SIAM Journal on Applied Mathematics
Article . 1985 . Peer-reviewed
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Analysis of a Model Biological Switch

Analysis of a model biological switch
Authors: Kath, W. L.; Murray, J. D.;

Analysis of a Model Biological Switch

Abstract

A model mechanism proposed by the second author [On pattern formation mechanisms for lepidopteran wing patterns and mammalian coat markings. Philos. Trans. R. Soc. Lond., B 295, 473-496 (1981)] for generating wing patterns and eyespots on butterflies and moths is based on a morphogen (S) activated biological switch for a gene product (g). We analyse one of the resulting partial differential equation systems, namely \[ S_ t=D\Delta S-kS,\quad g_ t=k_ 1S+\alpha g(g-k_ 2)(g_ c-g), \] where D, k, \(k_ 1\), \(k_ 2\), \(g_ c>k_ 2\) and \(\alpha\) are positive constants. We determine analytically the size of the spatial domain where \(g\to g_ c\) as \(t\to \infty\) after an influx of S at the origin. This gives the size of the eyespot in terms of the mechanism parameters. The analytical problem is a nontrivial singular perturbation expansion which we discuss in detail.

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United States
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Keywords

eyespot formation, biological switch, morphogen controlled pattern formation, Partial differential equations of mathematical physics and other areas of application, Other natural sciences (mathematical treatment), morphogenesis, 510, second order system, development of wing patterns, lepidoptera, General biology and biomathematics, Singular perturbations in context of PDEs

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
Green
bronze