E‐cadherin expression in canine cutaneous histiocytoma
Copyright policy )E‐cadherin expression in canine cutaneous histiocytoma
Canine cutaneous histiocytoma is a common skin tumour of Langerhans cell origin. Langerhans cells are members of the dendritic cell family of antigen‐presenting cells and are located in the epidermis. They are unique among the dendritic cell lineage in that they express high levels of the adhesion molecule E‐cadherin. The expression of E‐cadherin by the neoplastic Langerhans cells in 37 dogs with cutaneous histiocytoma was studied by flow cytometry and immunohistochemistry. In all the cases, these cells expressed E‐cadherin, whereas the infiltrating lymphocytes did not.
- University of Cambridge United Kingdom
Male, Skin Neoplasms, Histiocytoma, Benign Fibrous, Antibodies, Monoclonal, Cadherins, Flow Cytometry, Immunohistochemistry, Gene Expression Regulation, Neoplastic, Dogs, Langerhans Cells, Animals, Female, Dog Diseases
Male, Skin Neoplasms, Histiocytoma, Benign Fibrous, Antibodies, Monoclonal, Cadherins, Flow Cytometry, Immunohistochemistry, Gene Expression Regulation, Neoplastic, Dogs, Langerhans Cells, Animals, Female, Dog Diseases
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