The adenomatous polyposis coli protein.

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Aug 1999 English Publisher:BMJJournal:Molecular Pathology, volume 52, pages 169-173 (issn: 1366-8714, eissn: 1472-4154,

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Authors: I S, Näthke;

doi: 10.1136/mp.52.4.169

pmid: 10694935

pmc: PMC395695

The adenomatous polyposis coli protein.

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Abstract

Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell. First, APC is a component of the Wnt signalling pathway; second, APC may have a role in cell migration; finally, APC may regulate proliferation and apoptosis.

Related Organizations

University of Dundee
United Kingdom

Keywords

Cytoskeletal Proteins, Adenomatous Polyposis Coli Protein, Humans, Colorectal Neoplasms, Cell Physiological Phenomena, Neoplasm Proteins, Signal Transduction

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