Editor,—We have been assessing the recent in utero exposure to tobacco smoke in newborns from the Barcelona cohort of the AMICS study (Asthma Multicentre Infants Cohort Study).1The nursing personnel reported observational symptoms suggesting a possible neonatal nicotine withdrawal syndrome in some of the newborns from smoking mothers. The published data about this syndrome are scant and include conflicting positions. Whereas some papers admit a neonatal nicotine withdrawal syndrome,2 others reject it.3Although some investigators have shown neuroanatomic disorders in fetus and newborns exposed to smoke during pregnancy,4 5 we have not found any study published about the clinical consequences …