LIVER disease in dogs can develop as a result of many different insults. Mild damage may repair itself since the liver has tremendous regenerative capabilities. Severe and/or chronic damage, however, may lead to progressive and self‐perpetuating chronic liver disease. The clinical signs of liver disease are usually non‐specific and laboratory testing is essential for its recognition and evaluation. A definitive diagnosis is usually based on a combination of laboratory tests, radiography and/or ultrasound, and ultimately on histological examination of a liver biopsy.