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Gut; OpenAPC Global Initiative
Article . Conference object . 2021 . Peer-reviewed
License: CC BY
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Acute-on-chronic liver failure: a global disease.

Authors: Jonel Trebicka;

Acute-on-chronic liver failure: a global disease.

Abstract

Acute-on-chronic liver failure (ACLF) is a frequent complication in hospitalised patients with liver cirrhosis. A large body of data has been published in recent years, demonstrating that acute decompensation constitutes a dramatic turning point in the course of cirrhosis, with development of ACLF being the most severe form of acute decompensation (AD).1 Within the last decades, heterogeneous definitions of ACLF have been proposed in different regions of the world, that is, the European European Association for the Study of the Liver - Chronic Liver Failure (EASL-CLIF) definition, the NASCELD definition in North American and the East Asian APASL criteria. Due to those, epidemiological data on ACLF are heterogenous and not easy to compare. In Gut , Mezzano and colleagues have undertaken huge efforts to homogenise and compare the existing evidence.2 They present an extensive systematic review and meta-analysis on the burden of ACLF worldwide (figure 1A), which constitutes the largest epidemiological study on this subject to date.3 The authors were able to identify 30 prospective and retrospective cohort studies from around the world, which include 43 206 ACLF patients and 140 835 patients without ACLF. Strengths of this study are its scale and the robustness of data, which highlight the global significance of ACLF for patients and …

Subjects by Vocabulary

Microsoft Academic Graph classification: medicine.medical_specialty Cirrhosis business.industry Liver failure Retrospective cohort study Disease medicine.disease Epidemiology medicine Decompensation Acute on chronic liver failure business Intensive care medicine Complication

Keywords

Gastroenterology

1 Arroyo V, Moreau R, Jalan R. Acute-On-Chronic liver failure. N Engl J Med 2020;382:2137-45.

2 Mezzano G, Juanola A, Cardenas A. Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis. Gut 2022;71:148-55.

3 Mezzano G, Juanola A, Cardenas A. Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis. Gut 2022;71:148-55.

4 Trebicka J, Fernandez J, Papp M, et al. The predict study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology. J Hepatol 2020;73:842-54.

5 Trebicka J, Fernandez J, Papp M, et al. Predict identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis. J Hepatol 2020. doi:10.1016/j.jhep.2020.11.019. [Epub ahead of print: 20 Nov 2020].

6 Trebicka J, Fernandez J, Arroyo V, et al. Reply to: Correspondence on 'The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology'. J Hepatol 2021;74:480-1.

7 Arroyo V, Angeli P, Moreau R. Review The systemic inflammation hypothesis : Towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis. J Hepatol 2021:1-16.

8 Bernardi M, Angeli P, Claria J, et al. Albumin in decompensated cirrhosis: new concepts and perspectives. Gut 2020;69:1127-38. [OpenAIRE]

9 Trebicka J, Gu W, de Ledinghen V, et al. Two-Dimensional shear wave elastography predicts survival in advanced chronic liver disease. Gut 2021. doi:10.1136/ gutjnl-2020-323419. [Epub ahead of print: 21 January 2021].

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    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
14
Top 10%
Average
Top 10%
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