Problems of stopping trials early
Copyright policy )Problems of stopping trials early
When interim analyses of randomised trials suggest large beneficial treatment effects, investigators sometimes terminate trials earlier than planned. Gordon H Guyatt and colleagues show how this practice can have far reaching and harmful consequences
- University of Oxford United Kingdom
- McMaster University Canada
- Universitätsklinikum Tübingen Germany
- Bond University Australia
- Mayo Clinic United States
Time Factors, Endpoint Determination, Critical Illness, Adrenergic beta-Antagonists, Decision Making, Myocardial Infarction, Ethics, Research, Treatment Outcome, Research Design, Sepsis, Surgical Procedures, Operative, Humans, Insulin, Clinical Trials Data Monitoring Committees, Protein C, Randomized Controlled Trials as Topic
Time Factors, Endpoint Determination, Critical Illness, Adrenergic beta-Antagonists, Decision Making, Myocardial Infarction, Ethics, Research, Treatment Outcome, Research Design, Sepsis, Surgical Procedures, Operative, Humans, Insulin, Clinical Trials Data Monitoring Committees, Protein C, Randomized Controlled Trials as Topic
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).99 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!