Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ BMJarrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
BMJ
Article
Data sources: UnpayWall
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
BMJ
Article . 2005 . Peer-reviewed
Data sources: Crossref
BMJ
Article . 2005
versions View all 2 versions
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

Epilepsy in elderly people

Authors: Martin J, Brodie; Patrick, Kwan;

Epilepsy in elderly people

Abstract

Old age is the most common time in life to develop epilepsy.1 Making a secure diagnosis can be difficult, and piecing together an accurate picture of events may take some time. The clinical manifestations of seizures, the causes of epilepsy, and the psychosocial impact of the diagnosis can be different in older people than in younger ones. In addition, elderly people with epilepsy have two to three times higher mortality than the general population.w1 Age related physiological changes can affect the pharmacokinetics and pharmacodynamics of antiepileptic drugs. The situation is compounded by a paucity of good clinical studies. In this review we discuss the challenges and highlight recent developments in the diagnosis and management of epilepsy in elderly people. We searched Medline, Embase, and the Cochrane Collaboration with the key words “epilepsy”, “seizures”, “elderly”, “aged”, and “anticonvulsants”. We selected articles of interest from 1995 onwards and then hand searched these for earlier publications, focusing on those that specifically included elderly patients and covered clinically relevant topics. More than 11 million elderly people live in the United Kingdom, at least 1% of whom will have epilepsy. Compared with younger populations, elderly people are more prone to develop seizures, whether provoked by acute illnesses (“provoked” or “acute symptomatic” seizures) or without an obvious immediate cause (“unprovoked” seizures). Thirty per cent of acute seizures in elderly people will present as status epilepticus,w2 which carries a mortality approaching 40%.w3 The annual incidence of epilepsy (recurrent unprovoked seizures) rises from 90 per 100 000 in people between the ages of 65 and 69 to more than 150 per 100 000 for those over 80 (fig 1).2w4 With continuing ageing of the population, the number of older people with epilepsy is set to rise further, placing an increasing burden …

Related Organizations
Keywords

Adult, Aged, 80 and over, Epilepsy, Adolescent, Incidence, Middle Aged, United Kingdom, Age Distribution, Child, Preschool, Prevalence, Humans, Anticonvulsants, Child, Aged

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    162
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 1%
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
162
Top 10%
Top 1%
Top 1%
bronze