We report clinical courses and histopathological findings of excised blebs from two patients with recurrent blebitis. ### Case 1 A 79 year old man with a past history of lung cancer and diabetes mellitus underwent trabeculectomy with 5-fluorouracil in his right eye for a diagnosis of primary open angle glaucoma (POAG) in 1989. In January 1994, bleb leakage from an avascular bleb was confirmed for the first time and prophylactic topical erythromycin had been applied. In September 1994, he experienced ocular pain and hyperaemia in his right eye and blebitis was diagnosed. Culture of aqueous humour was positive for enterococcus. He was treated with topical ofloxacin, micronomicin, and a subconjunctival injection of amikacin and the infection resolved. After then, bleb leak was not observed at any regular visit. In March 1998, blebitis occurred with a bleb leak in the same …