A femtosecond laser microkeratome is becoming a popular device for performing lamellar cuts before laser ablation during laser-assisted in situ keratomileusis (LASIK) surgery, achieving good refractive outcomes and a low rate of complications.1–5 Inflammatory reactions at the interface after using a femtosecond laser for creating lamellar cuts have been communicated at ophthalmology meetings but not yet published in papers. We present a case of severe diffuse lamellar keratitis (DLK) after using IntraLase (IntraLase Corp, Irvine, CA) for performing LASIK surgery. A 32-year-old Caucasian male patient attended our clinic for refractive surgery. He had non-relevant medical or ocular history. The preoperative cicloplegic refraction was right eye, −1.25 sph, −1 cyl×80° visual acuity = 1 (decimal scale); left eye, −1.25 sph, −1.75 cyl×90° visual acuity = 1. Pachymetry …